Dera Ismail Khan, typically abbreviated to D.I. Khan, is a town in Khyber-Pakhtunkhwa Province, Pakistan. It is located on the West Bank of the Indus River, two hundred miles (320 km) west of Lahore and a hundred and twenty miles (190 km) northwest of Multan. The city is the capital of the district and tehsil of the same name.

D.I. Khan is known for its lacquered woodwork, glass and ivory ware, mats and sarongs.

Newer industries within town include sugar, soap, textile and oil milling. CRBC Canal is the major canal that provides water for irrigation. One among the foremost famous product of the district is the “Dhaki Date”, that is exported to the middle East, us, and Europe. The date is called after the dhaki in Dera Ismail Khan. The district additionally produces wheat, sugar cane, rice and noted variety of mango known as the langra. town has several famous persons in each field like Jaffar Khan and Abdul Wahid Qereshi.

Dera Ismail Khan has a classification with hot summers and mild winters. Precipitation mainly falls in 2 distinct periods: in the late winter and early spring from Feb to April, and in the monsoon in June and July.

Although town is comparatively new, rebuilt following the 1823 flood, several of its original structures remain — the original wall remains visible round the old town. A popular tourist destination is a pre-Islamic fort known as Bilot, thirty miles (48 km) from the Dera Ismail Khan on Dera Ismail Khan – Chashma main road. These ruins are situated on a hill.